The Children’s Center for Cancer and Blood Diseases (CCCBD) at Children’s Hospital Los Angeles (CHLA) is the largest pediatric hematology, oncology and blood and marrow transplant program in the western United States. The CCCBD created the Cell Therapy Program, aimed at accelerating the development of cell and immune based treatments. The Las Madrinas Endowment for Hematopoietic Stem Cell Research has supported the development of this game-changing program. Alan Wayne, MD and Michael Pulsipher, MD have been conducting cutting edge cell therapy trials on the the first-ever CHLA patients to be treated with engineered T-cells, all three of whom are now in remission. These trials hold tremendous potential for children who have relapsed or have not responded to traditional cancer therapy. Thanks to the Las Madrinas Endowment, CHLA researchers have the support they need to develop new therapies in hopes of improving the lives of children with cancer and other life-threatening conditions.